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[Blog] Considerations in Building Web Applications for the Amazon Cloud

    1. Licensing - If you stay Open Source you are OK... Commercial Licences may kill your budget..
    1. Persistence - Application persistence.. Amazon does not like filesystems, use DB for persistence...
    1. Horizontal Scalability. Not sure that this gets the point.. vertical scalabillity should work even better on Amazone. Anyone?
    1. Disaster Recovery. Its a distributed system - cope and be happy :)

Reference: http://broadcast.oreilly.com/2008/10/considerations-in-building-web.html